Serum α1 Antitrypsin Assay (α1-AT)

Α1 antitrypsin is a glycoprotein with 10% to 20% sugar, which is mainly synthesized by the liver and widely distributed in normal human serum and body fluids. It is the most important protease inhibitor in serum, and it also inhibits other enzymes such as thrombin and urokinase. It is also an acute phase reaction protein. In inflammatory diseases, α1 antitrypsin can enter the tissue fluid through capillaries. In the local area of ​​inflammation, the concentration is often high, which can play a certain role in the development of acute inflammatory. Basic Information Specialist classification: growth and development check classification: biochemical examination Applicable gender: whether men and women apply fasting: fasting Tips: Taking estrogen can increase α1-antitrypsin, so this drug should be banned before the test. Normal value The enzyme rate method (37 ° C) is 0.85 to 2.13 U/L. The immunoturbidimetric method was 14.2 to 36.4 μmol/L. Clinical significance Increased in infectious diseases (bacterial, viral), acute hepatitis, cirrhosis, liver necrosis, malignant tumors, collagen disease, pregnancy, brain trauma, surgery, systemic lupus erythematosus, drugs (estrogen, oral contraception) Medicine, adrenal steroids, prostaglandins, etc.), typhus, burn recovery period, etc. Reduce α1-AT deficiency, neonatal respiratory distress syndrome, severe hepatitis, acute pancreatitis, emphysema, duodenal ulcer, nephrotic syndrome, protein-loss gastrointestinal disorder, hyperthyroidism, diffusion Intravascular coagulation, malnutrition, immature children, early rejection of kidney transplantation, etc. Precautions 1, α1-antitrypsin elevation can be seen during pregnancy. 2. Taking estrogen can increase α1-antitrypsin. Inspection process Same as radioimmunoassay. Not suitable for the crowd No taboos. Adverse reactions and risks Subcutaneous hemorrhage: subcutaneous hemorrhage due to less than 5 minutes of compression time or blood draw technique.