Plasma coagulation factor VII activity assay

The determination of plasma coagulation factor VII activity is to measure the activity of plasma coagulation factor VII, ie prothrombinogen, in human body. The half-life of coagulation factor VII is the shortest (4-6 h), and the plasma content is low (0.5-2 mg/L). Therefore, it can be used as an early diagnostic indicator of protein synthesis dysfunction in patients with liver disease. 93% of patients with cirrhosis with factor VII activity <34% died within 10 months of follow-up, so it is considered to be an early predictor of prognosis in patients with cirrhosis, which can better identify liver transplant candidates. Coagulation factor VII activity can be significantly decreased in patients with cirrhosis, factor VII deficiency can lead to changes in platelet activity, combined with reduced platelet count to prolong bleeding time, therefore, in patients with cirrhosis with invasive diagnosis and treatment, factor VII activity should also be used. Perform an assessment of the risk of bleeding, not just the platelet count. In addition to diagnosis, recombinant factor VII can effectively correct coagulation abnormalities in patients with liver disease, which is conducive to the initiation of invasive examination. Basic Information Specialist classification: growth and development examination classification: blood examination Applicable gender: whether men and women apply fasting: fasting Tips: After 8 pm on the day before the medical examination, you should fast, so as not to affect the detection of indicators such as blood glucose in the second sky. Normal value The normal value is 2 to 4 mg/mL. Clinical significance Abnormal result 93% of patients with cirrhosis with factor VII activity <34% died within 10 months of follow-up, so it is considered to be an early predictor of prognosis in patients with cirrhosis, which can better identify liver transplant candidates. Coagulation factor VII activity can be significantly decreased in patients with cirrhosis, factor VII deficiency can lead to changes in platelet activity, combined with reduced platelet count to prolong bleeding time, therefore, in patients with cirrhosis with invasive diagnosis and treatment, factor VII activity should also be used. Perform an assessment of the risk of bleeding, not just the platelet count. In addition to diagnosis, recombinant factor VII can effectively correct coagulation abnormalities in patients with liver disease, which is conducive to the initiation of invasive examination. People who need to be examined have people with symptoms of cirrhosis. Low results may be diseases: liver disease precautions Taboo before the test: Do not eat too greasy, high-protein foods the day before the test, to avoid heavy drinking. The alcohol content in the blood directly affects the test results. After 8 pm on the day before the medical examination, you should fast. Requirements for examination: When taking blood, you should relax your mind to avoid the contraction of blood vessels caused by fear and increase the difficulty of blood collection. Inspection process Vascular blood collection was used for testing. Before venous blood collection, carefully check that the needle is securely installed and that there is air and moisture in the syringe. The needle used should be sharp, smooth, ventilated, and the syringe should not leak. Firstly, the skin was disinfected from the inside to the outside and clockwise from the selected venipuncture with a 30g/L iodine swab. After the iodine was volatilized, the iodized trace was wiped out in the same way with a 75% ethanol swab. Fix the lower end of the venipuncture site with the thumb of the left hand, hold the syringe syringe with the thumb and middle finger of the right hand, and fix the needle lower seat with the index finger, so that the bevel of the needle and the scale of the syringe are upward, and the needle is inclined along the vein to make the needle and the skin obliquely penetrate the skin at an angle of 30°. Then, through the vein wall, enter the venous cavity forward at an angle of 5°. After seeing the blood return, the needle will be probed into the spot to avoid the needle slipping out when the blood is collected; but it is not possible to use a deep puncture to avoid hematoma, and immediately remove the cuff. Needle plug can only be pumped out, can not be pushed in, so as to avoid injecting air into the vein to form a gas plug, causing serious consequences. Remove the syringe needle and slowly inject the blood into the anticoagulation tube along the tube wall to prevent hemolysis and foam. Not suitable for the crowd A patient with hemophilia and severe clotting factor deficiency. Adverse reactions and risks Dizziness or fainting: When blood is drawn, due to emotional overstress, fear, reflex caused by vagus nerve excitability, blood pressure drop, etc., the blood supply to the brain is insufficient to cause fainting or dizziness.