microcomplement hemolysis sensitivity test

The micro-complement hemolysis sensitivity test measures the sensitivity of red blood cells to complement in patients with paroxysmal nocturnal hemoglobinuria and groups red blood cells. It is a paroxysmal sleep hemoglobin-specific test. The people who need to be examined have fatigue, dizziness, pale, palpitations, shortness of breath, tinnitus, eye, etc., and people with paroxysmal aggravation or paroxysmal hemoglobinuria. Basic Information Specialist classification: growth and development examination classification: blood examination Applicable gender: whether men and women apply fasting: fasting Tips: Pay attention to rest and keep blood on an empty stomach. Normal value The result of the check is less than 15. Clinical significance Abnormal result If the test result is greater than 15, the diagnosis of paroxysmal nocturnal hemoglobinuria can be confirmed. Often with anemia or hemoglobinuria as the first symptom, hemoglobinuria is often obvious after sleep, light urine is wine color, heavy is soy sauce color. The interval of hemoglobinuria varies from time to time, and some have no hemoglobinuria episodes, but often have hemosiderin urine. There may be acute hemolysis symptoms such as fever, jaundice, and abdominal pain during the attack. Skin and mucous membranes may have mild bleeding, and some have mild swelling of the liver and spleen. Often complicated by venous thrombosis and cholelithiasis. Part of the coexistence with aplastic anemia, called aplastic anemia - paroxysmal nocturnal hemoglobinuria (AA-PNH) syndrome. Later, some can be converted into acute leukemia, aplastic anemia or myelofibrosis. Observe the amount of complement required to dissolve red blood cells, determine the sensitivity of red blood cells to complement, and classify PNH red blood cells into types I, II, and III. For each type of PNH patient, the percentage of these three types of red blood cells is determined according to the ratio of the three types of red blood cells to understand the development of the patient's condition and the therapeutic effect. The people who need to be examined have fatigue, dizziness, pale, palpitations, shortness of breath, tinnitus, eye, etc., and people with paroxysmal aggravation or paroxysmal hemoglobinuria. Precautions Taboo before the test: pay attention to rest, keep blood on an empty stomach. Do not wear clothes that are too small or too tight in cuffs to avoid the sleeves being too tight when blood is drawn or the sleeves are too tight after blood draw, causing blood vessels in the arms. Avoid strenuous exercise. Requirements for inspection: Checking is cumbersome, it may take a long time, and you need to wait patiently for results. Inspection process The peripheral blood mainly has ear lobe blood and fingertips to take blood. The baby can take blood from the heel. The earlobe has a lighter blood pressure, but the blood volume is less, especially those with smaller earlobes are more difficult to take blood. The blood pressure of the fingertips is more obvious, but the blood collection is more, especially for the blood routine test, the stable measurement results can be obtained. The skin should be cleaned before blood collection. Do not take blood immediately after entering the room in the cold outdoor winter. After the body is warm, especially the ear drops and hands should be warmed up. Do not use hot water to heat your hands before taking blood. Keep your fingers dry. If your fingertips have wounds, paronychia, redness or skin disease, avoid using this finger. Fingertip blood collection generally uses the ring finger, because the ring finger will not affect the daily function of the hand after piercing, of course, the middle finger or index finger can also be used, no special difference. When collecting blood in the ear, remove the earrings and other hanging ornaments on the earlobe. Do not hang up immediately after blood collection. After blood collection, apply sterile cotton blocks or other disinfecting hemostatic articles to pinch the needle and puncture the area. Do not touch the dirt. Do not wash your hands immediately. Isolation of bleeding red blood cells. Not suitable for the crowd Have a coagulopathy such as hemophilia. Adverse reactions and risks Subcutaneous hemorrhage: subcutaneous hemorrhage due to less than 5 minutes of compression time or blood draw technique.