Whole blood mercury

The human body contains about 13 mg of mercury. Mercury has two major classes of compounds, inorganic and organic. The amount of mercury ingested by mouth is mainly from the amount of mercury contained in rice and fresh fish, which is about half of the total intake. Inorganic mercury is absorbed by the intestinal tract by about 1%, while methylmercury is as high as 90%. Mercury is mainly excreted in urine and hair. Once the kidneys expel high concentrations of mercury, the kidneys are damaged. Mercury produces specific inhibition of a range of enzymes, causing these enzymes to become inactivated and poisoned. The toxicity of mercury mainly occurs in the kidney, brain, liver, lung, skin and other organs. Basic Information Specialist classification: growth and development check classification: biochemical examination Applicable gender: whether men and women apply fasting: fasting Reminder: Evaluate by mercury excretion, measured at the beginning of treatment, and measured at the same time each additional dose and subsequent treatment interval of 4 weeks. Normal value Whole blood <7.2 μg / L. Urine <26.4 μg / L. <38.9 μg/g creatinine. The conversion formula μg/L×4.985=nmol/L. Clinical significance Metallic mercury, mercury salts and organic mercury complexes may increase mercury levels. The toxicity is mainly from mercury vapor (metal mercury). The amount of inhalation per day as small as 0.1 to 1 mg may cause chronic poisoning. Mercury is introduced into tissues, such as thermometers, but rarely occurs. In the blood, mercury mainly binds to red blood cells, and a small part binds to proteins. As a result, the level of mercury in whole blood is significantly higher than that in plasma. Mercury is stored in all organs of the body, especially hair and nails, so hair analysis makes sense. There is no need to worry about mercury levels in whole blood <10μg/g, and the critical value is 20μg/L. Urinary excretion rate of 10 μg / g creatinine is normal, but the level of 50 μg / g creatinine should be concerned, the whole blood biological exposure index is 100μg / L alkyl mercury complex and 50μg / L inorganic and organic non-alkyl complex, An acceptable indicator of urinary Hg excretion is less than 200 μg/L. Acute mercury poisoning Clinically, there are few cases of acute mercury poisoning, depending on whether a large amount of mercury vapor is inhaled or a mercury solution is ingested. The main clinical features are nausea, gastritis, metallic taste, vomiting and abdominal pain. It is clinically determined that kidney damage is an innocence and uremia sign that occurs within 3 days. Chronic mercury poisoning is the result of long-term occupational exposure, such as fungicides for seed topdressing, wood protection solvents, mercury in the workplace, exposure to mercury nitrate due to working relationships, long-term use of mercury-containing bleach, and use of antifungal agents. Application, clinical symptoms are delayed. Excitement with mercury, tremors, headaches, cramps, changes in hair and nail color, and diffuse hair loss. Precautions Monitoring D-penicillin ammonia treatment: assessed by excretion of mercury, measured at the beginning of treatment, and again at each additional dose and subsequent treatment intervals of 4 weeks. Inspection process Atomic absorption spectrophotometry using cold vapor or hydride techniques. Not suitable for the crowd Generally no taboos. Adverse reactions and risks Discomfort: There may be pain, swelling, tenderness, and visible subcutaneous ecchymosis at the puncture site.