Hydroxylysine

Hydroxylysine is another product of collagen degradation. It mainly has two glycoside forms, GHYL (glycoside) and Glc.GHYL. Hydroxylysine and its glycoside product are not as high in urinary content as hydroxyproline, but because of its fixed content and not affected by food sources, tissue specificity is high, so there is more urinary hydroxyproline Better representation. One-third of the hydroxylysine in bone and skin is glycosylated, with a skin Glc.gHYL/GHYL of 1.6:1 and a bone of 17. Monoclonal antibodies to GHYL have been developed for clinical testing and are a more sensitive indicator of bone resorption. Basic Information Specialist classification: growth and development check classification: biochemical examination Applicable gender: whether men and women apply fasting: fasting Tips: Actively cooperate with the doctor's work. Normal value Not yet verified. Clinical significance Abnormal results Hydroxylysine is one of the raw materials for collagen biosynthesis, and collagen is associated with many human diseases. Such as bone formation is incomplete. That is, it is caused by collagen biosynthesis or post-transcriptional modification. It is now clear that due to type I collagen mutations, the severity of the disease varies depending on the location and nature of the mutation. In addition, some collagen diseases involve various collagen synthesis disorders or abnormalities in the activity of enzymes such as lysine hydroxylase and lysine oxidase during synthesis. For example, EhlersDanlos syndrome has more than 10 different collagen defects. The symptoms are mainly excessive joint extension, increased skin elasticity, fragility, weak blood vessels and subcutaneous mucin or subcutaneous fat nodules after trauma. Precautions Inappropriate crowd: None. Taboo before the test: poor rest, improper diet. Requirements for inspection: Actively cooperate with the doctor's work. Inspection process The sample of the body is taken, and after a certain treatment, the ratio of hydroxylysine in the sample is measured by a reagent or an instrument, thereby obtaining the content of hydroxylysine in the human body. Not suitable for the crowd Generally no taboos. Adverse reactions and risks Subcutaneous hemorrhage: subcutaneous hemorrhage due to less than 5 minutes of compression time or blood draw technique.