endothelin

Endothelin is a biologically active polypeptide consisting of 21 amino acids. Endothelin has a strong contraction of coronary arteries and renal arterioles, which stimulates the release of atrial natriuretic peptide, increases systemic blood pressure, and inhibits renin release. Endothelin is a multifunctional physiological regulator that participates in the development of various diseases such as shock and cerebrovascular diseases. Basic Information Specialist classification: growth and development examination classification: blood examination Applicable gender: whether men and women apply fasting: fasting Tips: In high blood pressure, myocardial infarction and kidney disease, the extent of endothelin elevation is closely related to the condition. The more severe the disease, the greater the increase of endothelin. After treatment, the endothelin is gradually reduced. Normal value (50.8 ± 7.58) ng / L (radioimmunoassay). Clinical significance Abnormal result Elevated in primary hypertension, acute myocardial infarction, angina pectoris, septic shock, kidney disease, uremia, cerebral hemorrhage, cerebral infarction, primary liver cancer, cirrhosis, duodenal ulcer, etc. Need to check the crowd Patients with symptoms such as shock. High results may be diseases: essential hypertension, pregnancy with thrombotic diseases In hypertension, myocardial infarction and nephropathy, the extent of endothelin elevation is closely related to the condition. The more severe the condition, the greater the increase of endothelin. After treatment, the endothelin is gradually reduced. Inspection process (1) Take a 10mm × 75mm plastic tube and add samples and reagents. Both the sample and the standard were duplicated. (2) Immediately after adding the PR separating agent, put it at 37 ° C for 30 min. Centrifuge at 3500 r/min for 20 min. The supernatant was removed by decompression. Measured on an automated gamma immunological counter. (3) The sample tube concentration can be directly given from the radio data processing program, or the sample tube concentration can be found on the standard curve with B/B0% as the ordinate. (4) Sample tube concentration (pg) × 4 (sample volume) ÷ 2 (plasma amount) yielded plasma ET1 pg/ml (ng/L). Not suitable for the crowd Generally no taboos. Adverse reactions and risks Generally not.