Antiglobulin test (Coombs test)

The antiglobulin test, also known as the Coombs test. Refers to a method of detecting incomplete antibodies in the blood. Positive in autoimmune diseases (such as autoimmune hemolytic anemia, cold agglutinin syndrome, paroxysmal cold hemoglobinuria, systemic lupus erythematosus, nodular arteritis), drug immunity and alloimmunization Sexual hemolytic anemia. Basic Information Specialist classification: cardiovascular examination classification: blood examination Applicable gender: whether men and women apply fasting: fasting Analysis results: Below normal: Normal value: no Above normal: negative: normal. Positive: Positive for lymphocytic leukemia. Tips: Do not eat too greasy, high-protein foods the day before the blood draw, avoid heavy drinking. Normal value negative. Clinical significance Antiglobulin test is commonly used for the diagnosis of hemolytic anemia, blood type identification, cross-matching and so on. Positive in autoimmune diseases (such as autoimmune hemolytic anemia, cold agglutinin syndrome, paroxysmal cold hemoglobinuria, systemic lupus erythematosus, nodular arteritis), drug immunity and alloimmunization Sexual hemolytic anemia. Positive results may be diseases: paroxysmal cold hemoglobinuria, angioimmunoblastic lymphadenopathy considerations First, the precautions before blood draw 1, do not eat too greasy, high-protein food the day before the blood, to avoid heavy drinking. The alcohol content in the blood directly affects the test results. 2. After 8 pm on the day before the medical examination, you should start fasting for 12 hours to avoid affecting the test results. 3, should relax when taking blood, to avoid the contraction of blood vessels caused by fear, increase the difficulty of blood collection. Second, should pay attention after blood draw 1. After blood is drawn, local compression is required at the pinhole for 3-5 minutes to stop bleeding. Note: Do not rub, so as not to cause subcutaneous hematoma. 2, the pressing time should be sufficient. There is a difference in clotting time for each person, and some people need a little longer to clotting. Therefore, when the surface of the skin appears to be bleeding, the compression is stopped immediately, and the blood may be infiltrated into the skin due to incomplete hemostasis. Therefore, the compression time is longer to completely stop bleeding. If there is a tendency to bleed, the compression time should be extended. 3, after the blood draw symptoms of fainting such as: dizziness, vertigo, fatigue, etc. should immediately lie down, drink a small amount of syrup, and then undergo a physical examination after the symptoms are relieved. 4. If there is localized congestion, use a warm towel after 24 hours to promote absorption. 3. Please inform the doctor about the recent medication and special physiological changes before the test. Inspection process Anti-human globulin test (Coombs test) including direct anti-human globulin test and anti-human globulin indirect test Direct anti-human globulin test The anti-human globulin direct test is used for allogeneic immunity caused by neonatal hemolytic disease, autoimmune hemolytic anemia, drug-induced hemolysis, and blood transfusion. Anti-human globulin indirect test The anti-human globulin indirect test is mainly used to detect the reaction of cells and sensitized antibodies in vitro. It can be used in human antibody test, blood group identification and compatibility test and special research, such as anti-human globulin consumption test, mixed agglutination reaction, Leukocyte and platelet antibody test tests, etc. Not suitable for the crowd Generally no taboos. Adverse reactions and risks Generally not.