Activated partial thromboplastin time (APTT)

Activated partial thromboplastin time is a more sensitive screening test for the endogenous coagulation system. Severe prothrombin (factor II), factor V, factor X, and fibrinogen lack liver disease, obstructive jaundice, and neonatal hemorrhagic disease. Intestinal sterilization syndrome, malabsorption syndrome, oral anticoagulant and low (no) fibrinemia. Basic Information Specialist classification: cardiovascular examination classification: biochemical examination Applicable gender: whether men and women apply fasting: not fasting Tips: Do not eat too greasy, high-protein foods the day before the blood draw, avoid heavy drinking. Normal value 35~45s. Clinical significance Abnormal results: The time to activate partial thromboplastin mainly reflects whether endogenous clotting is normal. The prolonged activation of partial thromboplastin is seen in: a, plasma factor VIII, factor IX and factor XI levels such as hemophilia A, hemophilia B and factor XI deficiency; b, severe prothrombin (factor II), factor V, factor X and fibrinogen deficiency liver disease, obstructive jaundice, neonatal hemorrhagic disease. Intestinal sterilization syndrome, malabsorption syndrome, oral anticoagulant and low (no) fibrinemia; c, enhanced fibrinolytic activity such as secondary, primary fibrinolysis, etc.; d, anticoagulant substances such as anticoagulant factor VIII or factor IX antibody in the blood circulation; e, systemic lupus erythematosus and some immune diseases. The shortened time of activation of partial thromboplastin is found in: a. In a hypercoagulable state, such as the procoagulant substance entering the blood and the activity of the blood coagulation factor is increased; b, thrombotic diseases such as myocardial infarction, unstable angina, cerebrovascular disease, diabetes with vascular disease, pulmonary infarction, deep vein thrombosis; c, pregnancy-induced hypertension syndrome and nephrotic syndrome. People who need to check: Chest discomfort, shortness of breath, abnormal weakness, body pain. High results may be diseases: postpartum blood stasis, drug-related immune hemolytic anemia considerations Before inspection: 1, do not eat too greasy, high-protein food the day before the blood, to avoid heavy drinking. The alcohol content in the blood directly affects the test results. 2. After 8 pm on the day before the physical examination, fasting should be done to avoid affecting the detection of indicators such as blood glucose in the second sky. When checking: When you draw blood, you should relax your mind, avoid the contraction of blood vessels caused by fear, and increase the difficulty of blood collection. After inspection: 1. After blood is drawn, local compression is required at the pinhole for 3-5 minutes to stop bleeding. Note: Do not rub, so as not to cause subcutaneous hematoma. 2, the pressing time should be sufficient. There is a difference in clotting time for each person, and some people need a little longer to clotting. Therefore, when the surface of the skin appears to be bleeding, the compression is stopped immediately, and the blood may be infiltrated into the skin due to incomplete hemostasis. Therefore, the compression time is longer to completely stop bleeding. If there is a tendency to bleed, the compression time should be extended. 3, after the blood draw symptoms of fainting such as: dizziness, vertigo, fatigue, etc. should immediately lie down, drink a small amount of syrup, and then undergo a physical examination after the symptoms are relieved. 4. If there is localized congestion, use a warm towel after 24 hours to promote absorption. Not suitable for the crowd: dizzy. Inspection process This test is to activate clotting factor XII (such as kaolin, citric acid, etc.) with contact factor activator in vitro, replace PF3 with partial thromboplastin (cephalin), and observe the time required for plasma coagulation after adding Ca2+. APTT is the most commonly used screening test for endogenous clotting factors. The prothrombin time of the specimen was longer than the normal control for more than 10 s. Not suitable for the crowd Have a coagulopathy such as hemophilia. Adverse reactions and risks Subcutaneous hemorrhage: subcutaneous hemorrhage due to less than 5 minutes of compression time or blood draw technique.