red blood cell aggregation

Erythrocyte aggregation reflects the ability of red blood cells to bind together. The factors affecting the aggregation of red blood cells mainly include the following aspects: 1 The bridging force of macromolecules, that is, the binding between red blood cells cannot be the direct adhesion between erythrocyte membranes, and there must be macromolecules "bridge" between cells and in calcium ions. The participation of cells can form the aggregation of cells. Therefore, the bridging force of macromolecules is the main force for cell aggregation. The more macromolecules, the stronger the aggregation of red blood cells. 2 Electrostatic Repulsive Force "The surface of the red blood cell membrane is negatively charged, which is a repulsive force for red blood cell aggregation. If certain factors reduce the surface charge of red blood cells (such as virus infection), the aggregation of red blood cells is enhanced. 3 Shear stress The size of the shear stress is the force that the red blood cells are subjected to in motion and is consistent with the direction of motion. The shear stress is proportional to the shear rate. This force can depolymerize the aggregated red blood cells. The greater the force, the more difficult the red blood cells are to form aggregates. 4 Red blood cell morphology The double-recessed disk-like structure of normal red blood cells has a large contact area between cells, and the cells are easy to aggregate. When the red blood cells are deformed, the spherical or elliptical shape is smaller for the cell contact area, and the aggregation force is weakened. Basic Information Specialist classification: cardiovascular examination classification: blood examination Applicable gender: whether men and women apply fasting: fasting Tips: After taking blood, you need to press it at the pinhole for 3-5 minutes to stop bleeding. Normal value 1s-111.28 to 17.28 mPa·s. Clinical significance Abnormal results: Increase thrombotic diseases, see hypertension, coronary atherosclerotic heart disease (coronary heart disease), stroke, pulmonary heart disease, diabetes, malignant tumors, peripheral vascular disease, shock, burns, etc. The people who need to be examined have headaches, dizziness, tinnitus, shortness of breath, shortness of breath, insomnia, numbness or tightness of the limbs, cyanosis, edema, palpitation and other symptoms. Precautions Before inspection: 1, do not eat too greasy, high-protein food the day before the blood, to avoid heavy drinking. The alcohol content in the blood directly affects the test results. 2. After 8 pm on the day before the medical examination, you should start fasting for 12 hours to avoid affecting the test results. 3, should relax when taking blood, to avoid the contraction of blood vessels caused by fear, increase the difficulty of blood collection. After inspection: 1. After blood is drawn, local compression is required at the pinhole for 3-5 minutes to stop bleeding. Note: Do not rub, so as not to cause subcutaneous hematoma. 2, the pressing time should be sufficient. There is a difference in clotting time for each person, and some people need a little longer to clotting. Therefore, when the surface of the skin appears to be bleeding, the compression is stopped immediately, and the blood may be infiltrated into the skin due to incomplete hemostasis. Therefore, the compression time is longer to completely stop bleeding. If there is a tendency to bleed, the compression time should be extended. 3, after the blood draw symptoms of fainting such as: dizziness, vertigo, fatigue, etc. should immediately lie down, drink a small amount of syrup, and then undergo a physical examination after the symptoms are relieved. 4. If there is localized congestion, use a warm towel after 24 hours to promote absorption. Inspection process The examination process: blood is drawn, blood is taken for examination, and venous blood is generally taken, and blood is drawn by a doctor or a nurse. The amount of blood drawn is determined according to the difference of the test content and the number of items. The blood volume is usually 2-20 ml, and the maximum is not more than 50 ml, and then the doctor's capillary viscometer method is used for calculation and examination. Not suitable for the crowd Have a coagulopathy such as hemophilia. Adverse reactions and risks Bleeding: After blood collection, use sterile cotton lump or other disinfecting hemostatic articles to tighten the needle to stop bleeding, especially for patients with coagulopathy should be given sufficient time to avoid bleeding.