beta thromboglobulin and platelet factor 4

Both beta-platelet globulin and platelet factor 4 are derived from alpha particles of platelets and are platelet-specific proteins. The concentration of both in plasma depends on the amount of platelet synthesis and release, and can also be related to renal excretion and clearance in the body. Diabetes with vascular disease, disseminated intravascular coagulation, vascular sclerosis, venous thrombosis, etc. Basic Information Specialist classification: growth and development examination classification: blood examination Applicable gender: whether men and women apply fasting: not fasting Tips: The diet should be regular and reasonable, that is, high-protein, high-vitamin foods. Normal value Beta platelet globin 0.9-5.5 μg/L (determined by enzyme-linked immunosorbent assay). 22.3-28.3 μg / L (radioimmunoassay). Platelet factor 4 1.0-5.5 μg/L (determined by enzyme-linked immunosorbent assay). Clinical significance Reduced in congenital or acquired reservoir disease (platelet alpha particle deficiency). Elevation suggests that platelets are activated and their release is hyperactive, seen in hypercoagulable states or thromboembolic diseases such as acute myocardial infarction, cerebrovascular disease, uremia, pregnancy-induced hypertension syndrome, nephrotic syndrome, diabetes with vascular disease, and blood vessels. Sclerosis, venous thrombosis, etc. High results may be diseases: uremia, acute myocardial infarction, pregnancy-induced hypertension syndrome, disseminated intravascular coagulation, venous thrombosis, α-storage disease considerations 1. Oral dipyridamole, indomethacin, benzenesulfonate, aspirin, etc., can inhibit the release of platelet factor 4, resulting in a decrease in the measurement results. 2. The application of heparin can increase the determination of platelet factor 4 factor. Inspection process The blood of the subject is extracted and measured. Not suitable for the crowd Those without examination indications should not be tested. Adverse reactions and risks 1. Infection: Pay attention to aseptic operation when collecting blood, avoid contamination of water and other parts at the blood collection site to avoid local infection. 2, bleeding: after the blood is given a full compression time, especially coagulopathy, bleeding tendency, to avoid local subcutaneous oozing, bruising and swelling.