Lung Epithelial Permeability (LEP) Assay

The lung epithelial cell permeability (LEP) assay is used to understand the permeability of alveolar epithelial cells and capillary endothelium. Adapted to the study of pulmonary capillary membrane function. When the alveolar epithelium is damaged, the clearance curve is a biphasic exponential curve, and the clearance time is accelerated. Basic Information Specialist Category: Respiratory Examination Category: Radionuclide Applicable gender: whether men and women apply fasting: fasting Tips: People with pulmonary ventilation function, lung epithelial cell function status, lung capacity and other aspects should first seek medical advice. Normal value When the alveolar epithelium is normal, the clearance curve is a single-phase exponential curve. The normal reference value depends on the situation of each hospital. Clinical significance Abnormal results: When the alveolar epithelium is damaged, the clearance curve is a biphasic exponential curve, and the clearance time is accelerated. Need to check the crowd: Regular smoking causes chronic cough, coughing and other patients. Precautions Requirements for inspection: 1. The location of aerosol deposition, stability in the body, and posture of exhalation all affect the measurement results. 2. The location of aerosol deposition is closely related to aerosol particle size, respiration rate and concentration. Excessively calm inhalation will result in maximum peripheral deposition, and rapid inhalation will cause more central deposition. 3. The time of inhalation of aerosols and the long time to record radioactivity in the lungs may also affect the determination of clearance rates. Excessive inhalation may mask rapid early and clear. 4. The pulmonary ventilation function, the functional status of the lung epithelial cells themselves, and the size of the lung volume all affect the measured values. 5. Pay attention to the radiation protection of patients and medical personnel and prevent environmental pollution. Preparation before examination: The lung ventilation function, lung epithelial cell functional status, and lung capacity were measured to evaluate the effect on the test. Inspection process A clearance curve was obtained after intravenous injection of a 99 Tcm-macromolecule polymerized human serum albumin having a diameter slightly larger than the diameter of the pulmonary capillaries. Not suitable for the crowd People with pulmonary ventilation, lung epithelial cell function status, lung capacity, etc. should seek medical advice first. Adverse reactions and risks May cause difficulty breathing.