Alpha-fetoprotein variant (AFPV)

Alpha-fetoprotein heterogeneity is of great significance for the differential diagnosis of primary liver cancer associated with elevated AFP and benign liver disease (urgent, chronic hepatitis, cirrhosis, etc.). Alpha-fetoprotein is a glycoprotein, acronym AFP. Under normal circumstances, this protein is mainly derived from embryonic liver cells. After about two weeks of birth, alpha-fetoprotein disappears from the blood, so the alpha-fetoprotein content in normal human serum is less than 20 micrograms per liter. However, when hepatocytes become cancerous, they restore the function of producing this protein, and as the disease progresses, its serum content will increase sharply. Alpha-fetoprotein becomes a specific clinical diagnosis of primary liver cancer. index. Basic Information Specialist classification: Oncology examination classification: biochemical examination Applicable gender: whether men and women apply fasting: not fasting Tips: Pregnant women can only be examined after one year of delivery. Normal value Often LCA-R accounts for 25% as the boundary for differential diagnosis. The normal value is that the alpha-fetoprotein content per liter of blood does not exceed 20 micrograms. Clinical significance Abnormal result 80% to 90% of LCA-R ≥ 25% may be primary liver cancer, and those below this value are benign liver diseases. People who need to be tested: people with primary liver cancer, cirrhosis, jaundice, ascites, liver cancer and other symptoms. Low results may be diseases: liver tumor, hepatitis, cirrhosis, chronic hepatitis, high results may be diseases: primary liver cancer, liver cancer, elderly primary liver cancer, hepatic hemangioma considerations Before the examination: pregnant women can only be examined after one year of delivery. After the examination: After the operation of liver cancer, if the AFP content decreases and the AFPV content is relatively constant, the postoperative recurrence is easy. Inspection process Radioimmunoassay: In a certain volume, a certain amount of antibody and a certain amount of radioactive antigen, the more non-radioactive antigen is added, the less radioactive antigen is bound to the antibody. Thus, if the antigen-bound antibody can be separated from the unbound antigen and the radioactivity of these antibodies can be measured by measuring the radioactivity, it is possible to estimate how many non-radioactive antigens are present. Not suitable for the crowd Not suitable for people: 1, pregnant women. Pregnant women can only be examined after one year of delivery. 2, no indication of indications should not be detected. Adverse reactions and risks 1. Infection: Pay attention to aseptic operation when collecting blood, avoid contamination of water and other parts at the blood collection site to avoid local infection. 2, bleeding: after the blood is given a full compression time, especially coagulopathy, bleeding tendency, to avoid local subcutaneous oozing, bruising and swelling.