Cancer Antigen 50 (CA50)

Cancer antigen 50, also known as sugar chain antigen 50, is a glycoprotein based on sialic acid ester and sialic acid glycoprotein, and is also a tumor antigen. Cancer antigen 50 is a non-specific broad-spectrum tumor marker with a certain cross-antigenicity with cancer antigen 19-9. It is mainly used for the auxiliary diagnosis of pancreatic cancer, colon/rectal cancer and gastric cancer. obvious. Basic Information Specialist classification: Oncology examination classification: immune examination Applicable gender: whether men and women apply fasting: fasting Tips: Before the examination, the diet is light, alcohol is forbidden, and a good sleep is guaranteed. Check the need for an empty stomach in the morning. Normal value The radioimmunoassay is less than 23,000 U/L. Clinical significance Cancer antigen 50 is a non-specific broad-spectrum tumor marker with a certain cross-antigenicity with cancer antigen 19-9. It is mainly used for the auxiliary diagnosis of pancreatic cancer, colon/rectal cancer and gastric cancer. obvious. Increased in pancreatic cancer (positive rate up to 87%), colon/rectal cancer, stomach cancer, lung cancer, liver cancer, ovarian cancer, breast cancer and other malignant tumors. Ulcerative colitis, cirrhosis, melanoma, lymphoma, autoimmune diseases, etc. are also increased. High results may be diseases: pancreatic cancer, carcinoid, gastric cancer, colorectal cancer First, the precautions before blood draw 1, do not eat too greasy, high-protein food the day before the blood, to avoid heavy drinking. The alcohol content in the blood directly affects the test results. 2. After 8 pm on the day before the medical examination, you should start fasting for 12 hours to avoid affecting the test results. 3, should relax when taking blood, to avoid the contraction of blood vessels caused by fear, increase the difficulty of blood collection. Second, should pay attention after blood draw 1. After blood is drawn, local compression is required at the pinhole for 3-5 minutes to stop bleeding. Note: Do not rub, so as not to cause subcutaneous hematoma. 2, the pressing time should be sufficient. There is a difference in clotting time for each person, and some people need a little longer to clotting. Therefore, when the surface of the skin appears to be bleeding, the compression is stopped immediately, and the blood may be infiltrated into the skin due to incomplete hemostasis. Therefore, the compression time is longer to completely stop bleeding. If there is a tendency to bleed, the compression time should be extended. 3, after the blood draw symptoms of fainting such as: dizziness, vertigo, fatigue, etc. should immediately lie down, drink a small amount of syrup, and then undergo a physical examination after the symptoms are relieved. 4. If there is localized congestion, use a warm towel after 24 hours to promote absorption. 3. Please inform the doctor about the recent medication and special physiological changes before the test. Inspection process The blood of the test subject is taken for measurement. Detection operation: 1. Tube number: 1 to 2 tubes are total radioactivity (T) tubes, 3 to 14 tubes are standard curve tubes, and 15 tubes are used to control serum and samples to be tested. Two sets of test tubes should be prepared, one for the sample addition reaction (a disc type plastic reaction plate can also be used). 2. Each reaction tube (except T tube) was added with C-50 antibody coated beads, and incubated at 37 ° C for 16 h (covering the upper mouth with a plastic film to prevent liquid evaporation). 3. Each tube was washed 3 times with water. 4. Move the beads into the corresponding measuring tube and measure the radioactivity count. Not suitable for the crowd Unchecked indications should not be tested. Adverse reactions and risks 1. Infection: Pay attention to aseptic operation when collecting blood, avoid contamination of water and other parts at the blood collection site to avoid local infection. 2, bleeding: after the blood is given a full compression time, especially coagulopathy, bleeding tendency, to avoid local subcutaneous oozing, bruising and swelling.