p16 Genetic Testing (MTS)

The P16 gene is also called the MTS (multipletumorsuppressor1) gene, which is a basic gene in the cell cycle, which directly participates in the regulation of the cell cycle, negatively regulates cell proliferation and division, and homozygous deletion is found in 50% of human tumor cell lines. Mutation, P16 is considered to be a new type of anti-cancer gene more important than P53. The P16 gene encodes a 16KD protein, the P16 protein, which is localized in the nucleus. The P16 protein is an inhibitor of CDK4 that acts on one of the key enzymes of the cell division cycle (CellDivisionCycle). Once its expression fails, it will cause malignant proliferation of cells, leading to malignant tumors. Basic Information Specialist Category: Oncology Inspection Category: Genetic Testing (DNA) Applicable gender: whether men and women apply fasting: not fasting Tips: Obey the doctor's arrangements when checking. Normal value No mutations. Clinical significance Mutation and deletion of P16 gene is an important indicator for judging the nature and prognosis of tumors. 1. The P16 gene has been found to be homozygous deletion and nonsense, missense and frameshift mutation in lung cancer, breast cancer, brain tumor, bone tumor, skin cancer, bladder cancer, kidney cancer, ovarian cancer and lymphoma, melanoma. It indicates that P16 gene is widely involved in tumor formation by deletion and mutation. It is of great clinical significance to detect whether P16 gene changes or not to judge the susceptibility of tumor and predict the prognosis of tumor. 2. The P16 gene is small in size, only 1/10 of P53, which is used for gene diagnosis and treatment, and is easier to operate. It is more practical for clinical tumor treatment. 3. The P16 tumor suppressor gene mutation occurred later, and the mutation positive rate increased with the clinical stage of the tumor. Precautions Specimen contamination is strictly avoided during the test. Inspection process Small cells were taken and then subjected to p16 gene detection (MTS). Not suitable for the crowd There are no absolute or relatively contraindicated people in this test. Adverse reactions and risks 1. Infection: Pay attention to aseptic operation when collecting blood, avoid contamination of water and other parts at the blood collection site to avoid local infection. 2, bleeding: after the blood is given a full compression time, especially coagulopathy, bleeding tendency, to avoid local subcutaneous oozing, bruising and swelling.