Serum Human Laminin (LN)

Human laminin is a non-collagen structural protein in the extracellular matrix. It is mainly synthesized by endothelial cells, stem cells and fat storage cells in the liver, and it is a main component of the basement membrane. It plays a key role in the assembly of the basement membrane, forming a network structure on the cell surface and immobilizing the cells on the basement membrane. When liver fibrosis occurs, human laminin binds to type IV collagen to form an endothelial basement membrane, resulting in fibrosis. Serum human laminin assay is one of the important indicators to observe the degree of liver fibrosis in patients with chronic hepatitis. Basic Information Specialist classification: Digestive examination classification: biochemical examination Applicable gender: whether men and women apply fasting: fasting Tips: Before the examination, the diet is light and alcohol is prohibited. Check that the morning is on an empty stomach. Normal value Enzyme-linked immunosorbent assay (ELISA) 20 to 80 μg / L. (Note that the kits used in each laboratory are different and the reference range is different.) Clinical significance 1, elevated in liver cirrhosis, chronic hepatitis liver fibrosis. 2, serum LN levels are often parallel to type IV collagen, HA, etc., and have important value in the diagnosis of liver fibrosis, especially portal hypertension. It has also been found that LN is associated with tumor invasion, metastasis, and the like. Chronic hepatitis (moderate) > 140 ng / ml, cirrhosis > 160 ng / ml. 3, in addition to the increase in primary liver cancer, many other cancer patients can also appear elevated serum LN levels, clinically should be identified. High results may be diseases: liver cirrhosis, chronic hepatitis, primary liver cancer considerations Fasting before the blood test, fasting for eight hours. Inspection process Take appropriate blood samples and immediately send them for inspection. The LN content in serum, body fluids and tissues was determined by enzyme-linked immunosorbent assay (ELISA) or radioimmunoassay and a second antibody as a separating agent. Not suitable for the crowd Inappropriate people: Generally there are no people who are not suitable. Adverse reactions and risks Discomfort: There may be pain, swelling, tenderness, and visible subcutaneous ecchymosis at the puncture site.