serum amyloid A

SAA is an acute phase protein and binds to plasma high density lipoprotein (HDL). Clinical studies are now focusing on the type of SAA during acute reactions to inflammatory diseases. Compared with the well-proven acute phase protein-CRP, SAA has been used to test whether it has any advantages in the diagnosis of acute inflammatory diseases remains to be determined. The average serum SAA concentration in normal subjects is 2.33mg/L. The determination of SAA concentration is more sensitive to the diagnosis of acute rejection of renal transplantation than serum Cr. In the case of exclusion of infection, the abnormal increase of SAA is acute in renal transplantation. The rejection reaction has great diagnostic value. Serum amyloid A concentration is a sensitive indicator of early inflammation in infectious diseases, which helps to diagnose inflammation, assess its activity, monitor its activity and treatment. However, serum amyloid A detection is more conclusive than C-reactive protein in patients diagnosed with viral infection, renal transplant rejection (especially in patients undergoing immunosuppressive therapy) and cystic fibrosis patients treated with corticosteroids. . The study found that serum amyloid A is most closely related to disease activity in cases of inflammatory arthritis. Simultaneous detection of C-reactive protein and serum amyloid A can improve the diagnostic sensitivity of infection. For patients with amyloid A amyloidosis, treatment with a goal of restoring serum amyloid A levels to normal can improve the condition. Basic Information Specialist classification: Digestive examination classification: biochemical examination Applicable gender: whether men and women apply fasting: fasting Analysis results: Below normal: Rare. Normal value: Serum amyloid A: 1-10mg/L Above normal: Similar to CRP, to assess the progression of the acute phase reaction, which began to rise after approximately 8 hours of the inflammatory response. An elevated SAA in the metastatic stage of malignancy usually shows a higher value than a tumor-limited organ stage. Chronic elevation of SAA concentration in patients with rheumatoid arthritis, tuberculosis or leprosy. negative: Positive: Tips: Before the examination, the diet is light and alcohol is prohibited. Check for an empty stomach in the morning. Normal value <10 mg/L is determined by the measurement method. Clinical significance 1. Similar to CRP to assess the progress of the acute phase reaction. SAA is a sensitive parameter that begins to rise after approximately 8 hours of inflammatory response and exceeds the upper limit of the reference range earlier than CRP, whereas the median value of CRP in normal subjects is approximately 10 times the upper limit of the reference range. Only 5 times in SAA. Slight infections, for example, many viral infections, are more common in SAA than in CRP. In infectious diseases, the absolute increase in SAA is higher than that in CRP, so SAA measurements, especially for "normal" and micro-acute reactions, provide a better identification. Usually about 2/3 of patients with colds have elevated SAA, but less than 1/2 of patients have the same increase in CRP. In cases of viral infection, elevated concentrations of SAA and CRP are seen in those infected with adenovirus. 2. The reaction forms of SAA and CRP are parallel in the recovery phase of acute infection, which applies to both bacterial and viral infections. 3. SAA is not elevated in lupus erythematosus and ulcerative colitis. 4. The elevation of SAA in the stage of malignant tumor metastasis usually shows a higher value than the stage in which the tumor is confined to the organ. 5. For transplant rejection, SAA testing is a fairly sensitive indicator. In a study of kidney transplant recipients, 97% of rejections were based on an increase in SAA. In the irreversible transplant rejection test, the average concentration was 690±29 mg/L, and the relevant level of reversible rejection was 271±31 mg/L. 6. Chronic elevation of SAA in patients with rheumatoid arthritis, tuberculosis or leprosy is a prerequisite for the synthesis of AA-starch fibers, which is also used to diagnose secondary amyloidosis. High results may be diseases: pediatric renal amyloidosis, rheumatoid arthritis in the elderly, leprosy considerations Currently, a small number of commercial testing methods exhibit variability, and once WHO provides SAA reference products (currently under development), comparability will improve. Inspection process Immediately after blood collection, the test can be performed by enzyme-labeled immunoassay, radioimmunoassay, immuno-scattering or immunoturbidimetry. Not suitable for the crowd no. Adverse reactions and risks no.