Serum haptoglobin (Hp)

The haptoglobin, also known as haptoglobin, is an α2 globulin synthesized by the liver, which accounts for about 1% of total plasma protein and can form a certain complex with hemoglobin in the river. When hemolysis occurs, the amount of free hemoglobin in the plasma increases, the amount of globin bound to it increases, and the plasma haptoglobin decreases, which is a very sensitive indicator of intravascular hemolysis. Basic Information Specialist classification: growth and development check classification: biochemical examination Applicable gender: whether men and women apply fasting: fasting Analysis results: Below normal: 1. Clinically, Hp is mainly used for the diagnosis of hemolytic anemia. The Hp content of various hemolytic anemias was significantly reduced, even to the extent that they could not be measured. In mild hemolysis, free Hb in plasma was completely eliminated by binding to Hp. At this time, free Hb was not detected in plasma, and only Hp was decreased. When the amount of free Hb exceeds the Hp binding capacity, it is detected. Therefore, Hp reduction can be used as a sensitive indicator for the diagnosis of mild hemolysis. 2. Hp reduction in acute and chronic hepatocyte disease (such as hepatitis). 3. Infectious mononucleosis, congenital non-binding globulinemia Hp may be decreased or absent. 4. Acute and chronic infections, tissue damage, and malignant diseases can also be increased. 5. Megaloblastic anemia. Normal value: Rocket electrophoresis: 1.0-2.7g/L Radioimmunoassay: 0.8-2.7g/L Hemoglobin binding method: 0.3-2.0g/L Above normal: Elevated in 1. The normal or increased Hp content in the serum of extrahepatic obstructive jaundice; 2. Trauma, burn; 3. Malignant tumor; 4. Acute and chronic infection; 5. Tuberculosis; 6. Rheumatism, such as rheumatism, rheumatoid Arthritis, lupus erythematosus; 7. coronary heart disease; 8. nephrotic syndrome; 9. endocrine disorders, contraceptives or steroids, and normal pregnant women. negative: Positive: Tips: Androgen can promote protein anabolism and increase serum Hp content; while dextran, estrogen, oral contraceptives, and tamoxifen reduce serum Hp. Therefore, avoid taking these drugs before testing. Normal value Rocket electrophoresis 1.0-2.7g/L. The radioimmunoassay method is 0.8-2.7 g/L. The hemoglobin binding method is 0.3-2.0 g/L. Clinical significance Reduced in 1. Clinically, Hp is mainly used for the diagnosis of hemolytic anemia. The Hp content of various hemolytic anemias was significantly reduced, even to the extent that they could not be measured. In mild hemolysis, free Hb in plasma was completely eliminated by binding to Hp. At this time, free Hb was not detected in plasma, and only Hp was decreased. When the amount of free Hb exceeds the Hp binding capacity, it is detected. Therefore, Hp reduction can be used as a sensitive indicator for the diagnosis of mild hemolysis. 2, acute and chronic liver cell disease Hp decreased (such as hepatitis). 3, infectious mononucleosis, congenital non-binding globulinemia Hp can be decreased or absent. 4, acute and chronic infections, tissue damage, malignant diseases, etc. can also increase. 5, megaloblastic anemia. Raised in 1. The Hp content in the serum of extrahepatic obstructive jaundice is normal or increased. 2, trauma, burns. 3. Malignant tumors. 4. Acute and chronic infections. 5. Tuberculosis. 6. Rheumatism, such as rheumatism, rheumatoid arthritis, lupus erythematosus. 7. Coronary heart disease. 8. Nephrotic syndrome. 9. Endocrine disorders, those who use contraceptives or steroids, and normal pregnant women. Low results may be diseases: globin-forming anemia, globin-producing anemia retinopathy considerations 1. Specimens should be fresh serum-free serum or serum samples placed within -20 °C for 2 weeks. 2, androgen can promote protein anabolism, increase serum Hp content; while dextran, estrogen, oral contraceptives, tamoxifen reduce serum Hp. Therefore, avoid taking these drugs before testing. Inspection process Take 2ml of empty blood, not anticoagulation, do not hemolyze. Immediately after venous blood collection, the test method was determined by electrophoresis. Not suitable for the crowd no. Adverse reactions and risks no.