Serum γ-glutamyl transpeptidase (γ-GTP)

R-glutamyltranspeptidase (r-GT) is found in kidney, pancreas, liver, spleen, intestine, brain, lung, skeletal muscle and myocardium, with the largest number of kidneys, followed by pancreas and liver, and embryonic stage It is most abundant in the liver and is mainly distributed in the liver cytoplasm and intrahepatic bile duct epithelium in the liver. The γ-GT in normal human serum is mainly from the liver. The normal value is 3 to 50 μ/L (γ-glutamyl p-nitrobenzamine method). This enzyme is only mildly elevated in acute hepatitis, chronic active hepatitis, and cirrhosis. However, when obstructive jaundice, the enzyme flows back into the blood due to excretion disorder. In the case of primary liver cancer, the enzyme is synthesized in the liver, which can cause a significant increase in blood transpeptidase, even more than 10 times normal. Alcoholism ν-GT is also significantly elevated, which is helpful in diagnosing alcoholic liver disease. In acute hepatitis, ν-GT drops to normal and is slower than transaminase, such as ν-GT continues to rise, suggesting a shift to chronic liver disease. In chronic liver disease, especially cirrhosis, a persistently low ν-GT indicates a poor prognosis. ν-GT is also used to diagnose liver metastases in malignant tumors. Basic Information Specialist classification: Digestive examination classification: liver function test Applicable gender: whether men and women apply fasting: fasting Tips: Do not eat too greasy, high-protein foods the day before the blood draw, avoid heavy drinking. The alcohol content in the blood directly affects the test results. Fasting for 12 hours before taking blood, taking fresh blood for examination. Normal value 1. IFCC recommendation Male 11 ~ 50U / L, Female 7 ~ 32U / L. 2, dynamic method 8~50U/L. 3. Rate method Male <40U/L, Female <30U/L. (Note the specific reference value depends on each laboratory.) Clinical significance Abnormal result 1, specificity increased (hepatobiliary disease). (1) bile stasis biliary obstruction, drug-induced hepatitis, primary biliary cirrhosis. (2) chronic hepatitis (chronic > inactive), alcoholic hepatitis (alcoholic hepatitis > non-specific hepatitis > cirrhosis > fatty liver). (3) Liver cirrhosis (active, non-compensatory > inactive, compensatory). (4) Liver malignant tumors Primary liver cancer and metastatic liver cancer. 2. Non-specific mild elevation. Found in chronic pancreatitis, acute myocardial infarction, diabetes, pancreatic cancer and so on. 3. Reduce. Found in pregnancy or oral contraceptives caused by bile stasis, congenital hypogamma-GTP, renal failure and so on. High results may be diseases: liver cirrhosis, viral hepatitis, alcoholic liver disease, congenital hepatic cyst, liver cancer, drug-induced liver disease, pediatric liver cirrhosis, post-hepatitis syndrome, congenital liver fibrosis Before inspection: 1, do not eat too greasy, high-protein food the day before the blood, to avoid heavy drinking. The alcohol content in the blood directly affects the test results. 2. Fasting for 12 hours before taking blood, taking fresh blood for inspection. When checking: When you draw blood, you should relax your mind, avoid the contraction of blood vessels caused by fear, and increase the difficulty of blood collection. After inspection: 1. After blood is drawn, local compression is required at the pinhole for 3-5 minutes to stop bleeding. Note: Do not rub, so as not to cause subcutaneous hematoma. 2, the pressing time should be sufficient. There is a difference in clotting time for each person, and some people need a little longer to clotting. Therefore, when the surface of the skin appears to be bleeding, the compression is stopped immediately, and the blood may be infiltrated into the skin due to incomplete hemostasis. Therefore, the compression time is longer to completely stop bleeding. If there is a tendency to bleed, the compression time should be extended. 3, after the blood draw symptoms of fainting such as: dizziness, vertigo, fatigue, etc. should immediately lie down, drink a small amount of syrup, and then undergo a physical examination after the symptoms are relieved. 4. If there is localized congestion, use a warm towel after 24 hours to promote absorption. Inspection process The blood of the subject is extracted and detected by immunological methods. Not suitable for the crowd Taboo population: The people who need to be tested have urine sugar, cirrhosis, indigestion, and abnormal liver function. Adverse reactions and risks 1. Infection: Pay attention to aseptic operation when collecting blood, avoid contamination of water and other parts at the blood collection site to avoid local infection. 2, bleeding: after the blood is given a full compression time, especially coagulopathy, bleeding tendency, to avoid local subcutaneous oozing, bruising and swelling.