Serum type III collagen

Type III collagen, the earliest reported type III procollagen peptide (PIIIP), which has been widely used in clinical practice. It is a polypeptide in which type III procollagen is cleaved by an amino terminal endopeptidase. PIIIP is helpful in distinguishing between chronic active hepatitis and chronic persistent hepatitis. The level of PIIIP in chronic liver is significantly increased, while the content in slow-moving liver is not significantly different from that in normal people. Basic Information Specialist classification: Digestive examination classification: biochemical examination Applicable gender: whether men and women apply fasting: fasting Tips: Before the examination, the diet is light and alcohol is prohibited. Check for an empty stomach in the morning. Normal value 0.6 μg/ml. Clinical significance In 1979, a radioimmunoassay (RIA) for the determination of serum PIIIP was established abroad, and it was confirmed that serum PIIIP content in liver fibrosis is related to hepatic inflammation, necrosis and liver fibrosis, but mainly related to liver fibrosis, so serum PIIIP is still An important marker of liver fibrosis. PIIIP is not meaningful for the diagnosis of childhood liver disease, it increases with the age of children. Many scholars have reported that serum PIIIP is a good indicator of adult liver fibrosis activity, which can make up for the lack of dynamic observation of liver biopsy. Patients with cirrhosis are significantly elevated, but in the late stage of cirrhosis, due to the decreased synthesis rate of type III procollagen peptide, serum PIIIP is lower than earlier. PIIIP is helpful in distinguishing between chronic active hepatitis and chronic persistent hepatitis. The level of PIIIP in chronic liver is significantly increased, while the content in slow-moving liver is not significantly different from that in normal people. High results may be diseases: liver fibrosis, cirrhosis, lipoproteinosis, viral hepatitis Simultaneous detection of HA, LN and other serum liver fibrosis indicators can improve the accuracy and reliability of liver fiber diagnosis. Inspection process Immediately after blood collection, the test principle was based on human PCIII (hpcIII) as an antigen, and the rabbits were immunized to obtain high specificity and high titer antibodies. Labeling of hpcIII with 125I: Determination of PCIII in human serum by double antibody plus PEG non-equilibrium RIA. Detection method is determined by radioimmunoassay. Not suitable for the crowd Special diseases: Patients with hematopoietic dysfunction, such as leukemia, various anemia, myelodysplastic syndrome, etc., unless the examination is essential, try to draw less blood. Adverse reactions and risks Risk of infection: If you use an unclean needle, you may be at risk of infection.