Glucose-6-phosphate dehydrogenase

G-6-PD is derived from red blood cells and catalyzes glucose-6-phosphate. The resulting NAD-PH is a coenzyme of glutathione reductase. Reduced glutathione (GSH) maintains hemoglobin stability and erythrocyte membrane integrity. Necessary conditions. In the case of erythrocyte G-6-PD deficiency, the erythrocyte membrane loses sulfhydryl protection and its function is impaired, resulting in hemolysis. The G-6-PD deficiency (trap) gene is on the X chromosome, which is mostly inherited by females. Basic Information Specialist classification: growth and development check classification: biochemical examination Applicable gender: whether men and women apply fasting: fasting Analysis results: Below normal: Mainly used for the diagnosis of related hemolytic anemia. Such as: 1, congenital: congenital G-6-PD deficiency hemolytic anemia, faba bean disease. 2, drug-induced hemolytic anemia: such as primaquine, sodium salicylate, sulfonamide, aspirin and so on. 3, non-pharmaceutical hemolytic anemia: such as viral or bacterial infections, neonatal jaundice. Normal value: G-6-PD activity: 7.75-10.93U/gHb Above normal: Rare. negative: Positive: Tips: When you take blood, you should relax your mind, avoid the contraction of blood vessels caused by fear, and increase the difficulty of blood collection. Normal value G-6-PD activity was 9.34 ± 1.59 U/g Hb (37 ° C). Clinical significance Clinical examination of red blood cells G-6-PD is mainly used to diagnose related hemolytic anemia. Such as 1, congenital: congenital G-6-PD deficiency hemolytic anemia, faba bean disease. 2, drug-induced hemolytic anemia: such as primaquine, sodium salicylate, sulfonamide, aspirin and so on. 3, non-pharmaceutical hemolytic anemia: such as viral or bacterial infections, neonatal jaundice. Low results may be diseases: glucose-6-phosphate dehydrogenase deficiency, autoimmune hemolytic anemia considerations Note before inspection: 1. Do not take the medicine at will, all drugs need to be prescribed by the doctor. 2. Avoid eating broad beans. 3, wardrobes and toilets can not put mothballs (smell pills). 4. Do not use gentian violet (purple syrup). 5, found that the child has the above-mentioned hemolytic symptoms, take the hospital as soon as possible. 6. Carry the G6PD Memo Card with you to inform the doctor when you are ready to seek medical attention. Before inspection: 1, do not eat too greasy, high-protein food the day before the blood, to avoid heavy drinking. The alcohol content in the blood directly affects the test results. 2. After 8 pm on the day before the medical examination, you should start fasting for 12 hours to avoid affecting the test results. 3, should relax when taking blood, to avoid the contraction of blood vessels caused by fear, increase the difficulty of blood collection. After inspection: 1. After blood is drawn, local compression is required at the pinhole for 3-5 minutes to stop bleeding. Note: Do not rub, so as not to cause subcutaneous hematoma. 2, the pressing time should be sufficient. There is a difference in clotting time for each person, and some people need a little longer to clotting. Therefore, when the surface of the skin appears to be bleeding, the compression is stopped immediately, and the blood may be infiltrated into the skin due to incomplete hemostasis. Therefore, the compression time is longer to completely stop bleeding. If there is a tendency to bleed, the compression time should be extended. 3, after the blood draw symptoms of fainting such as: dizziness, vertigo, fatigue, etc. should immediately lie down, drink a small amount of syrup, and then undergo a physical examination after the symptoms are relieved. 4. If there is localized congestion, use a warm towel after 24 hours to promote absorption. Inspection process Inspection method: draw blood. Not suitable for the crowd no. Adverse reactions and risks no.