Urinary 17-ketocorticosteroid (17-KS)

Urine 17-ketocorticosteroids are metabolites of adrenocortical hormones and androgens. Increased in adrenal hyperfunction, anterior pituitary hyperfunction, testicular stromal tumor, adrenal gland abnormalities, hyperthyroidism, and the application of adrenocorticotropic hormone, androgen and corticosteroids. Basic Information Specialist classification: urinary examination classification: urine / kidney function test Applicable gender: whether men and women apply fasting: not fasting Analysis results: Below normal: Decreased in adrenal insufficiency, anterior pituitary dysfunction, testicular dysfunction, hypogonadism, chronic digestive disease, cirrhosis and hypothyroidism. Normal value: Urine 17-ketocorticosteroid (male): 31-69 μmol/24h urinary 17-ketocorticosteroid (female): 21-56 μmol/24h urine Above normal: Increased in adrenal hyperfunction, anterior pituitary hyperfunction, testicular stromal tumor, adrenal gland abnormalities, hyperthyroidism, and the application of adrenocorticotropic hormone, androgen and corticosteroids. negative: Positive: Tips: Patients should wash the vulva before leaving the urine to avoid urine contamination of the vulva secretions. The container used should be clean and free from contamination. Do not mix chemicals such as detergents, disinfectants and preservatives to avoid affecting the inspection results. Women should prevent vaginal discharge from getting into the urine. Normal value Chemical assay Male 31 ~ 69μmol / 24h urine. Female 21 ~ 56μmol / 24h urine. Under the age of 8 2.7 ~ 9μmol / 24h urine. 8~12 years old 6.2 ~ 17.3μmol / 24h urine. 12~15 years old 17.3 ~ 45.1μmol / 24h urine. Columnar analysis Male 34.7 ~ 86.7μmol / 24h urine. Female 24.3 to 69.3 μmol / 24h urine. 0 to 10.4 μmol / 24 h urine under 8 years old. (Note the specific reference value depends on each laboratory.) Clinical significance Abnormal result Increased in adrenal hyperfunction, anterior pituitary hyperfunction, testicular stromal tumor, adrenal gland abnormalities, hyperthyroidism, and the application of adrenocorticotropic hormone, androgen and corticosteroids. Decreased in adrenal insufficiency, anterior pituitary dysfunction, testicular dysfunction, hypogonadism, chronic digestive disease, cirrhosis and hypothyroidism. Need to check the crowd Endocrine disorders in patients. Low results may be diseases: primary adrenal insufficiency results may be high disease: pediatric adrenal cortex and medullary hyperplasia syndrome precautions Preparation before inspection: 1, the patient washes the vulva before leaving the urine to avoid urine contamination of the vulva secretions. The container used should be clean and free from contamination. Do not mix chemicals such as detergents, disinfectants and preservatives to avoid affecting the inspection results. 2, women should prevent vaginal discharge into the urine. 3. Leave 24 hours of urine. Requirements for inspection: A part of the urine is discharged first to wash away the bacteria remaining in the urethra and the anterior urethra, and then the middle part of the urine is taken for examination. Not suitable for people: There is no inappropriate crowd. Inspection process Simplified method; blood cortisol concentration was measured as the base value at 8 am on the first day. Midnight dexamethasone: 1.5mg, the next day at 8 o'clock in the morning to retest blood sterols. Regular method: blood cortisol concentration at 8 o'clock in the morning or urinary 17-hydroxycorticosteroid content at 24 o'clock in the morning. The next day, dexamethasone 0.75 mg was administered three times a day for 4 days. Afterwards, the blood cortisol concentration or urinary 17-hydroxyl was reviewed. Corticosteroid levels were compared to pre-dose. Not suitable for the crowd There is no inappropriate crowd. Adverse reactions and risks no.