Urinary 17-hydroxy-corticosteroid (17-OH-CS)

Urine 17-hydroxycorticosteroid is a hormone secreted by the adrenal cortex in the urine and its metabolites. Increased in adrenal hyperfunction (Cushing syndrome), adrenal hyperplasia, adrenal cortex and bilateral hyperplasia, hyperthyroidism, severe irritation and trauma, obesity, pancreatitis. Basic Information Specialist classification: urinary examination classification: urine / kidney function test Applicable gender: whether men and women apply fasting: not fasting Analysis results: Below normal: Reduced in adrenal insufficiency such as Addison's disease, Sheehan's syndrome, chronic liver disease such as liver disease, tuberculosis. Normal value: Urine 17-hydroxy-corticosteroids (chemical assay male): 14-30μmol/24h urinary 17-hydroxy-cortical ulceration 2-29μmol/24h urine Above normal: Increased in adrenal hyperfunction (Cushing syndrome), adrenal hyperplasia, adrenal cortex and bilateral hyperplasia, hyperthyroidism, severe irritation and trauma, obesity, pancreatitis. negative: Positive: Tips: Patients should wash the vulva before leaving the urine to avoid urine contamination of the vulva secretions. The container used should be clean and free from contamination. Do not mix chemicals such as detergents, disinfectants and preservatives to avoid affecting the inspection results. Women should prevent vaginal discharge from getting into the urine. Normal value Chemical assay Male 14 ~ 30μmol / 24h urine. Female 12 ~ 29μmol / 24h urine. Columnar analysis Male 17.3 to 79.7 μmol / 24h urine. Female 10.4 ~ 52μmol / 24h urine. Old people and children are slightly lower. (Note the specific reference value depends on each laboratory.) Clinical significance Abnormal result Increased in adrenal hyperfunction (Cushing syndrome), adrenal hyperplasia, adrenal cortex and bilateral hyperplasia, hyperthyroidism, severe irritation and trauma, obesity, pancreatitis. Reduced in adrenal insufficiency such as Addison's disease, Sheehan's syndrome, chronic liver disease such as liver disease, tuberculosis. Need to check the crowd Hyperthyroidism. High results may be diseases: pediatric adrenal cortex and medullary hyperplasia syndrome precautions Requirements for inspection: 1, the patient washes the vulva before leaving the urine to avoid urine contamination of the vulva secretions. The container used should be clean and free from contamination. Do not mix chemicals such as detergents, disinfectants and preservatives to avoid affecting the inspection results. 2, women should prevent vaginal discharge into the urine. 3, stay 24 hours urine, 5 ~ 10ml hydrochloric acid antiseptic. Preparation before inspection: There are many factors affecting this test, such as stress, malnutrition, chronic wasting disease, cirrhosis, renal dysfunction, and a variety of drugs and foods that can interfere with the test, should be noted. The doctor should be informed of the above medical history before the examination. Not suitable for people: Chronic wasting disease, cirrhosis, and renal dysfunction. Inspection process Porter and Silber's colorimetric method is a common method for determining urinary 17 hydroxysteroids (17-OHCS). The 17-OHCS in acidic urine (pH 2.4-2.6) was extracted with an extractant, Porter-Silber reagent was added to the extracted phase, and the mixture was kept in a water bath at 60 ° C for 30 min to complete the Porter-Silber color reaction. The essence of this reaction is that 17-OHCS reacts with a sulfuric acid solution of phenylhydrazine hydrochloride to form a 21-aldehyde which produces yellow hydrazine. The content of 17-OHCS in the urine is calculated by the same colorimetric comparison with the same treatment. Not suitable for the crowd Chronic wasting disease, cirrhosis, and renal dysfunction. Adverse reactions and risks no.