cyclic guanosine monophosphate

Cyclic guanosine monophosphate is widely distributed in various tissues, and its content is about 1/10 to 1/100 of cAMP, which is produced by guanylate cyclase catalyzing GTP and is decomposed by phosphodiesterase. cGMP has the opposite effect of cAMP. cGMP has the action of acetylcholine, inhibits myocardial contractility, lowers heart rate, increases neuronal excitability, stimulates leukocyte lysosomes to release hydrolase, stimulates lymphocyte division and proliferation, inhibits gluconeogenesis and excites parasympathetic nerves. Features. Basic Information Specialist classification: growth and development check classification: biochemical examination Applicable gender: whether men and women apply fasting: fasting Tips: Do not use hot water to heat your hands before taking blood. Keep your fingers dry. If your fingertips have wounds, paronychia, redness or skin disease, avoid using this finger. Normal value Plasma (4.75 ± 0.31) nmol / L. Cerebrospinal fluid (3.1 ± 0.42) nmol / L. Clinical significance Abnormal result 1, cardiovascular disease acute myocardial infarction, plasma cGMP increased significantly, up to 20nmol / L or more, old myocardial infarction generally increased no more than 15nmol / L. The mean value of plasma cGMP in hypertension and coronary heart disease was higher than normal. 2, thyroid disease thyroid hyperthyroidism plasma cGMP concentration is slightly higher than normal, hypothyroidism plasma cGMP decreased. 3, kidney disease chronic nephritis plasma cGMP increased, uremia patients increased significantly, and cAMP / cGMP ratio decreased. 4, immune function cGMP can stimulate lymphocyte proliferation alone, participate in the promotion of lymphocyte transformation process. 5. Plasma cGMP is elevated in patients with yin deficiency of traditional Chinese medicine. Yang deficiency is significantly reduced. People who need to be checked High blood pressure, abnormal mental excitement, and renal dysfunction. Low results may be diseases: high thyroid dysfunction in the elderly may result in high disease: acute myocardial infarction, hyperthyroidism Before inspection The skin should be cleaned. Do not take blood immediately after entering the room in the cold outdoor winter. After the body is warm, especially the ear drops and hands should be warmed up. Do not use hot water to heat your hands before taking blood. Keep your fingers dry. If your fingertips have wounds, paronychia, redness or skin disease, avoid using this finger. After the examination, use a sterile cotton ball to squeeze the puncture site for 3-5 minutes to stop bleeding, and at the same time relax the sleeves of the upper jaw. Do not rub the puncture site to avoid "cyan" in local congestion. Do not touch the puncture point after hemostasis to avoid infection. Occasionally, due to factors such as fasting, poor rest, and nervousness, the mountain is now "stunned": dizziness, pale face, weak body, and difficulty breathing. At this point, you should immediately ask the doctor for help. At the same time, you can lie flat on the waiting chair, loosen your belt, take a deep breath, and get relief after a few minutes with the help of a doctor. People with a history of "halo" can bring some candy, chocolate, etc. the next time they take the blood. After taking the blood, they can be taken immediately to avoid such a phenomenon. Finally, ask the doctor about the time and place of the laboratory report to get timely diagnosis and treatment. Inspection process After blood draw, the isotope labeling method is used. Isotope labeling is a microanalytical method for labeling research objects using radionuclides as tracers. The commonly used isotopes in biology are the main elements that make up protoplasts, namely H, N, C, S, P, and O. isotope. Not suitable for the crowd no. Adverse reactions and risks no.