β-Hydroxybutyric acid

The β-hydroxybutyric acid (β-HB) has a molecular weight of 104.1 kD, which accounts for about 70% of the total amount of the ketone body. In patients with severe acidosis, the increase in NADH production in the body due to acidosis leads to an increase in the ratio of acetylacetate to β-HB to acetoacetate from a normal 2:1 to 16:1. The method for determining β-HB is the most sensitive, rapid, economical and simple method by enzymatic method, and is a commonly used method in clinical practice. Basic Information Specialist classification: growth and development check classification: biochemical examination Applicable gender: whether men and women apply fasting: fasting Analysis results: Below normal: No clinical significance. Normal value: Β-hydroxybutyric acid: 0.031-0.263 mmol/L Above normal: Ketotoxicity. negative: Positive: Tips: The blood sample is separated within 24 hours after removal, and the sample is stored at 4 ° C for no more than 1 week. Normal value 0.031 to 0.263 mmol/L. <0.7 mmol/L. (colorimetric method) Clinical significance Serum β-HB assay is mainly used for the differential diagnosis of ketotoxicosis and the follow-up monitoring of such patients. High results may be diseases: Diabetes ketoacidosis precautions A heavily hemolyzed sample (hemoglobin up to 110 g/L) reduced the concentration of β-HB by 0.8 mmol/L. A sample of severe jaundice with bilirubin >273 μmol/L resulted in a significant decrease in β-HB value. Inspection process Determined by enzymatic method. Not suitable for the crowd no. Adverse reactions and risks no.