Serum β2-microglobulin

2-2-microglobulin, molecular weight 11800. The human body synthesizes about 150 mg per day, which is present in all nucleated cells except red blood cells and placental trophoblast cells, mainly produced by lymphocytes, and is related to lymphocyte surface recognition function and the role of killer cell receptors. Almost all nucleated cells in the body can synthesize β2 microglobulin and attach to the cell surface. The amount of β2 microglobulin produced daily by the same individual remains constant and is secreted in various body fluids. Determination of β2 microglobulin in blood, urine, and cerebrospinal fluid is important for the diagnosis of various diseases. Basic Information Specialist classification: growth and development examination classification: blood examination Applicable gender: whether men and women apply fasting: fasting Analysis results: Below normal: No clinical significance. Normal value: Serum β2-microglobulin (ELISA method): 0.8-2.4 mg/L Above normal: 1. Renal dysfunction. 2, malignant tumors, multiple myeloma, lymphocytic leukemia, malignant lymphoma. 3, immune disorders SLE (systemic lupus erythematosus), sjögren (Sjogren) syndrome, rheumatoid arthritis, sarcoma-like disease, AIDS. 4, tube graft rejection. negative: Positive: Tips: The level of β2 microglobulin in the elderly over 60 years old has a tendency to increase with age. Normal value The ELISA method (enzyme-linked immunosorbent assay) is 0.8 to 2.4 mg/L. Clinical significance Increase: 1. Renal dysfunction. 2, malignant tumors, multiple myeloma, lymphocytic leukemia, malignant lymphoma. 3, immune disorders SLE (systemic lupus erythematosus), sjögren (Sjogren) syndrome, rheumatoid arthritis, sarcoma-like disease, AIDS. 4, tube graft rejection. High results may be diseases: renal insufficiency, precautions for rheumatoid arthritis in the elderly Urine β2 microglobulin elevation: See "urine physical and chemical examination" in the urine β2 microglobulin. Cerebrospinal fluid β2 microglobulin reference value: adult <4.7mg / L; children 0.6 ~ 1.6mg / L. Increased in acute cerebral infarction, meningitis, encephalitis, polyneuritis, etc. seen in adults, also seen in children with bacterial encephalitis, viral encephalitis, epilepsy and so on. The level of β2 microglobulin in the elderly over 60 years old has a tendency to increase with age. Inspection process Determined by enzyme-linked immunosorbent assay. Not suitable for the crowd Generally taboo people. Adverse reactions and risks Generally no complications.